A recent study sheds light on the frequency and risk factors for surgical site infection (SSI) and its significance for patient and graft outcomes in liver transplantation. Conducted as part of the Swiss Transplant Cohort Study, the research provides valuable data on infection rates, risk factors and possible prevention strategies.
Liver transplantation is a life-saving procedure but carries risks such as SSIs, which can lead to complications, prolonged hospitalization and even graft failure. A study by Schreiber and colleagues looked at 1,158 liver transplant patients over 12 years and found that 6 percent developed an SSI within 90 days – a lower rate than previously reported. Most SSI were organ-space infections, affecting deeper tissues and organs.
The main risk factors included previous liver transplants and living donations. SSIs were also associated with an increased risk of graft failure and death within one year, highlighting the need for improved prevention strategies.
The prevention of SSIs requires a combination of different measures. While certain risk factors, such as the complexity of the operation, cannot be avoided, others can be addressed, for example, through better blood glucose control, intraoperative maintenance of normothermia and optimized preparation of the surgical site. Studies have also shown that bundled interventions are more effective than individual measures.
The University Hospital Zurich plays a central role in the Swiss Transplant Cohort Study and accounts for one third of the patients included. As a leading transplant center, the USZ provides essential clinical data and biological samples to advance research on liver transplantation and infection prevention.
This study highlights the need for further research to improve prevention techniques and antibiotic strategies. Through continued efforts, physicians can help reduce SSIs and optimize outcomes for liver transplant patients.
See Publication Editorial Comment