Research Group Anna-Maria Hoffmann-Vold, Prof. Dr. med.

Our project investigates the clinical trajectories of ILD in SSc. We aim to identify patterns of progression by assessing different clinical definitions of progression, ultimately informing more personalized treatment strategies.

Our project investigates the clinical trajectories of ILD in SjD. We aim to identify patterns of progression by assessing different clinical definitions of progression, ultimately informing more personalized management strategies.

Our project investigates disease trajectories of ILD in SSc. We aim to identify patterns of disease progression across all organs using AI in collaboration with Michael Krauthammer’s group at USZ.

Our project investigates disease trajectories of organ manifestations and lymphoma development in SjD. We aim to identify organ manifestations—focusing particularly on ILD, kidney involvement (tubulointerstitial nephritis, glomerulonephritis), and peripheral nervous system involvement (polyneuropathy)—as well as associated risk factors and patterns of disease progression across all affected organs, ultimately to inform more personalized management strategies.

While SjD is typically diagnosed in middle-aged women, it also affects men, children, and older adults, who tend to have more aggressive disease with higher risks of lymphoproliferative complications. This project aims to investigate these distinct clinical profiles to better understand underlying processes and support personalized treatment strategies.

Ultrasound of the major salivary glands is increasingly valued as a diagnostic tool, a possible marker for disease activity, and for lymphoma detection, though it is not yet included in ACR/EULAR classification criteria. This project aims to assess the correlation between abnormal ultrasound findings in major salivary glands and biopsy results from minor glands. Ultrasound could offer a cost-effective, non-invasive alternative to biopsy in SjD screening, pending further research to confirm its reliability.

Our project investigates disease trajectories of organ manifestations in ESD. We aim to identify organ manifestations, risk factors, and patterns of disease progression across all organs in ESD, ultimately informing more personalized management strategies.

Our project takes a basic and translational approach to investigating ILD in SSc by analyzing lung tissue samples. By integrating clinical data with molecular and cellular analysis from lung biopsies, we aim to uncover key pathways driving disease progression, ultimately leading to more targeted and personalized treatment strategies for ILD in SSc.

Our project takes a basic and translational approach to investigating GIT disease in SSc by analyzing gut tissue samples. By integrating clinical data with molecular and cellular analysis from gut biopsies, we aim to uncover key pathways driving disease progression, ultimately leading to more targeted and personalized treatment strategies for GIT disease in SSc.

Our project employs a basic and translational approach to investigate organ manifestations in SjD, analyzing tissue samples, primarily from labial salivary glands and blood. By integrating clinical data with molecular and cellular analysis from these samples, we aim to uncover key pathways driving disease progression, paving the way for more targeted and personalized treatment strategies for SjD.

Our project takes a basic and translational approach to investigating organ manifestations in ESD by analyzing tissue samples, primarily from skin and blood. By integrating clinical data with molecular and cellular analysis from these samples, we aim to uncover key pathways driving disease progression, ultimately leading to more targeted and personalized treatment strategies for EDS/HSD.