DCIS (ductal carcinoma in situ = breast cancer precursor) Radiotherapy

Radiation therapy (also known as radiotherapy) is used for pre-cancerous breast lesions (also known as pre-invasive lesions or precancerous lesions) in order to achieve a cure for the disease together with surgery (curative radiotherapy). Radiotherapy focuses high-energy X-rays on the tumor or remaining tumor cells in order to kill them in a targeted manner.

Procedure

Ductal carcinoma in situ (DCIS) is a precancerous condition. The term “in situ” means “in place”. This means that the DCIS does not form any offshoots in the body. Treatment is nevertheless recommended, as it can cure the disease. If left untreated, DCIS can develop into invasive breast cancer in 30 – 50% of patients.

Radiotherapy always takes place after the operation as an outpatient treatment, is non-invasive (i.e. does not require anesthesia) and can therefore be easily integrated into everyday private and professional life. Fractionated treatment is necessary for DCIS. This means that the radiation dose is divided into many small daily fractions and the treatment is usually carried out over a period of 3-4 weeks. Anti-hormonal therapy, which is sometimes necessary, can also be carried out in parallel with radiotherapy. Radiotherapy is usually tolerated without any problems and only takes a few minutes. Close and personal support is a matter of course for us.

The Department of Radiation Oncology at the USZ uses only the most modern techniques for precise breast irradiation with few side effects. Standard techniques in our clinic include intensity-modulated radiotherapy (IMRT) and the technical advancement VMAT (volumetric modulated arc therapy), “fast” high-energy electrons, image-guided adjustment and radiation (IGRT), as well as treatment using the breath-hold technique (DIBH) for left-sided DCIS.

Radiotherapy procedure

In our department, you will be cared for by proven experts in the treatment of DCIS.

  • Duma MN, Baumann R, Budach W, Dunst J, Feyer P, Fietkau R, Haase W, Harms W, Hehr T, Krug D, Piroth MD, Sedlmayer F, Souchon R, Sauer R; Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO). Heart-sparing radiotherapy techniques in breast cancer patients: a recommendation of the breast cancer expert panel of the German society of radiation oncology (DEGRO). Radiation Oncol. 2019 Oct;195(10):861-871. English. doi: 10.1007/s00066-019-01495-w. Epub
  • Nilsson C, Valachis A. The role of boost and hypofractionation as adjuvant radiotherapy in patients with DCIS: a meta-analysis of observational studies. Radiother Oncol. 2015 Jan;114(1):50-5. doi: 10.1016/j.radonc.2015.01.001. Epub 2015 Jan 14. PMID: 25596912.
  • Cuzick J, Sestak I, Pinder SE, Ellis IO, Forsyth S, Bundred NJ, Forbes JF, Bishop H, Fentiman IS, George WD. Effect of tamoxifen and radiotherapy in women with locally excised ductal carcinoma in situ: long-term results from the UK/ANZ DCIS trial. Lancet Oncol. 2011 Jan;12(1):21-9. doi: 10.1016/S1470-2045(10)70266-7. Epub 2010 Dec 7. PMID: 21145284; PMCID: PMC3018565.

Responsible professionals

Claudia Linsenmeier, Dr. med.

Senior Attending Physician, Department of Radiation Oncology

Tel. +41 44 255 26 73
Specialties: Focus on breast/gynecology, Gastro-Intestinal Radio-Oncology, Pediatric radio-oncology

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