CCCZ Research Area – Oncogenic Signaling
Focus Topics
- Intercellular signals and intracellular signal transduction pathways
- Developmental biology
- Stem cell biology
- Treatment resistance
- Cellular mechanisms and molecular control of tissue invasion
- Inflammation
- Cell death
- Tumor biomarkers
- Tissue Repair/Wound Healing
- Tumor Models
- Outcome prediction of pharmacological interventions
- Development of personalized cancer therapies
- Organs: Brain, CRC, Childhood Leukemia, pediatric sarcomas, pleural mesothelioma
Specific Aims
- Understand how cell-to-cell communication controls growth and patterning in development and disease
- Understand molecular mechanisms of inflammation-associated diseases
- Identify processes on the molecular, cellular and tumor pathophysiological level that regulate the response to radiotherapy and thereby co-determine treatment outcome
- Determine molecular mechanisms underlying melanoma initiation, growth, and metastasis formation, with a particular focus on embryonic programs reactivated during tumorigenesis
- Develop novel diagnostic and therapeutic approaches
Research groups
- Konrad Basler, Prof. Dr., WNT and hedgehog signalling in colorectal cancer
- Martin Baumgartner, Prof. Dr., Pediatric molecular neuro-oncology research
- Beat Bornhauser, Prof. Dr., Cell death and leukemia
- Jean-Pierre Bourquin, Prof. Dr. med., Pediatric Onoclogy
- Ralph Fritsch, PD Dr. med., Experimental GI Oncology Lab
- Raghvendra Dubey, Prof. Dr., Dubey Group
- Alex Hajnal, Prof. Dr., Hajnal Lab
- Jason Holland, Prof. Dr., Radiochemistry and imaging science
- Michael Hottiger, Prof. Dr., Cell signalling in inflammatory associated diseases
- Martin Pruschy, Prof. Dr., Laboratory for applied radiobiology
- Isabelle Schmitt-Opitz, Prof. Dr. med., Department of Thoracic Surgery
- Lukas Sommer, Prof. Dr., Stem Cell Biology
- Achim Weber, Prof. Dr. med., Weber Lab
- Sabine Werner, Prof. Dr., Tissue repair and cancer
- Andreas Wicki, Prof. Dr. med., Experimental Oncology Lab
- Lynn Wong, Prof. Dr., Cell Death and regulation of Inflammation
- Thorsten Zenz, Prof. Dr. med., Lymphoma Research