CCCZ Research Area – Epigenetics, Genetics and Genomics
Focus topics
- DNA repair pathways
- Genome (in)stability
- DNA damage response
- Replication stress
- Gene regulation
- Functional (epi)genomics
- DNA methylation, histone modifiers, chromatin remodelers
- Genome engineering
- Develop targeted precision anti-cancer therapies
Specific Aims
- Understand the mechanistic basis of genome rearrangements arising during perturbed DNA replication in stem- and somatic cells, playing key roles in cancer onset and therapy
- Understand how deregulation of genome integrity maintenance in cancer cells creates vulnerabilities that can be exploited therapeutically
- Identify novel molecular mechanisms of gene regulation and revealing potential targets for cancer therapy
- Decipher the molecular framework of DNA damage signalling and repair for the rational design of targeted anti-cancer therapies
- Develop new therapeutic strategies for the treatment of cancer, which are based on targeting specific DNA-repair pathways
- Understand how embryonic cell programs are harnessed by cancer and to model tumor formation in vivo
- Implement personalized medicine through the identification and functional characterization of key genes and pathways
- Identify better predictive biomarkers for precision oncology and novel targets
Research groups
- Matthias Altmeyer, Prof. Dr., Genome instability in cancer and aging
- Felix Beuschlein, Prof. Dr. med.,Department of Endocrinology, Diabetology and Clinical Nutrition
- Jacob Corn, Prof. Dr., Corn Lab
- Ana Guerreiro Stücklin, MD PhD, Translational Brain Tumor Research
- Pavel Janscak, Prof. Dr., Mechanism of DNA repair
- Mitch Levesque, Prof. Dr., Translational Dermato-Oncology
- Massimo Lopes, Prof. Dr.,Replication stress in cancer onset and therapy
- Giancarlo Marra, Prof. Dr., Colorectal tumorigenesis
- Holger Moch, Prof. Dr. med., Urogenital cancer translational research
- Anne Müller, Prof. Dr.,Immunobiology of bacterial infection and cancer
- Hanspeter Nägeli, Prof. Dr., DNA repair, histone modifiers, chromatin remodelers
- Chantal Pauli, Prof. Dr. med., Pauli Group
- Lorenza Penengo, Prof. Dr., Ubiquitin – Based Regulation of Genome Stability
- Gunnar Rätsch, Prof. Dr., Biomedical Informatics Group
- Gerhard Rogler, Prof. Dr. med, Gastroenterology and Hepatology
- Raffaella Santoro, Prof. Dr., Santoro Group
- Alessandro Sartori, Prof. Dr., DNA Damage and Repair
- Beat Schäfer, Prof. Dr., Pediatric Onoclogy
- Gerald Schwank, Prof. Dr., Translational Genome Editing
- Manuel Stucki, Prof. Dr., Genome Instability and Cancer
- Didier Surdez, Prof. Dr. Bone Sarcoma Research Laboratory