Career
| Since 2022 | Attending Physician, Institute of Anesthesiology, USZ |
|---|---|
| 2022 | Specialist in Anesthesiology FMH |
| 2020 – 2022 | Resident, Institute of Anesthesiology, USZ Cardiac anesthesia rotation |
| 2016 – 2020 | Postdoctoral Scientist, Institute of Pharmacology and Toxicology, UZH |
| 2015 – 2016 | Resident, Intensive Care Medicine, Düsseldorf University Hospital |
| 2011 – 2016 | Resident, Institute of Anesthesiology, University Hospital Düsseldorf Rotation cardiac anesthesia, pediatric anesthesia |
| 2013 | Promotion |
| 2011 | Degree in Human Medicine, University of Tübingen |
Publications
Bhat MA, Esmaeili A, Neumann E, Balakrishnan K, Benke D (2022) Targeting the interaction of GABAB receptors with CHOP after an ischemic insult restores receptor expression and inhibits progressive neuronal death. Front Pharmacol. 13:870861
Werynska K, Gingras J, Benke D, Scheurer L, Neumann E, Zeilhofer HU (2021) A Glra3 phospho-deficient mouse mutant establishes the critical role of PKA-dependent phosphorylation and inhibition of glycine receptors in spinal inflammatory hyperalgesia. Pain. 162:2436-2445
Neumann E, Küpfer L, Zeilhofer HU (2020) The alpha2/alpha3 GABAA receptor modulator TPA023B alleviates not only the sensory but also the tonic affective component of chronic pain in mice. Pain. 162:421-431
Tudeau L, Acuna M, Albisetti G, Neumann E, Ralvenius W, Scheurer L, Poe M, Cook J, Johannssen H, Zeilhofer HU (2020) Mice lacking spinal α2GABAA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype. Brain Res. 1741:146889
Neumann E, Rudolph U, Knutson DE, Li G, Cook JM, Hentschke H, Antkowiak B, Drexler B (2019) Zolpidem activation of alpha 1-containing GABAA receptors selectively inhibits high frequency action potential firing of cortical neurons. Front Pharmacol. 9:1523
Neumann E, Ralvenius WT, Acuña MA, Rudolph U, Zeilhofer HU (2018) TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors. Neuropharmacology. 143:71-78
*Ralvenius WT, *Neumann E, Pagani M, Acuña MA, Benke D, Wildner H, Benke D, Fischer N, Rostaher A, Schwager S, Detmar M, Frauenknecht K, Aguzzi A, Hubbs JL, Rudolph U, Favrot C, Zeilhofer HU (2018) Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors. Nat commun. 9:3230
* both first-authors contributed equally.
Klinger-Gratz PP, Ralvenius WT, Neumann E, Kato A, Nyilas R, Lele Z, Katona I, Zeilhofer HU (2018) Acetaminophen Relieves Inflammatory Pain through CB1 Cannabinoid Receptors in the Rostral Ventromedial Medulla. J Neurosci. 38:322-334
Armbruster A, Neumann E, Kötter V, Hermanns H, Werdehausen R, Eulenburg V (2018) The GlyT1 Inhibitor Bitopertin Ameliorates Allodynia and Hyperalgesia in Animal Models of Neuropathic and Inflammatory Pain. Front Mol Neurosci. 10:438
Neumann E, Brandenburger T, Santana-Varela S, Deenen R, Köhrer K, Bauer I, Hermanns H, Wood JN, Zhao J, Werdehausen R. (2016) MicroRNA-1-associated effects of neuron-specific brain-derived neurotrophic factor gene deletion in dorsal root ganglia. Mol Cell Neurosci. 75:36-43
Neumann E, Hermanns H, Barthel F, Werdehausen R, Brandenburger T (2015) Expression changes of microRNA-1 and its targets Connexin 43 and brain-derived neurotrophic factor in the peripheral nervous system of chronic neuropathic rats. Mol Pain 11:39
Schlösser L, Barthel F, Brandenburger T, Neumann E, Bauer I, Eulenburg V, Werdehausen R, Hermanns H (2015) Glycine transporter GlyT1, but not GlyT2, is expressed in rat dorsal root ganglion – possible implications for neuropathic pain. Neurosci Lett. 600:213-219
Rüsch D, Neumann E, Wulf H, Forman SA (2012) An allosteric coagonist model for propofol effects on α1/β2/γ2L GABAA receptors. Anesthesiology 116:47-55
Research focus
- Neuropharmacology
- Spinal pain control through inhibitory neurotransmission