This study demonstrates a new mechanism in which chronic inflammation perpetuates fibrosis via activation of JUN, CD47, IL-6, and the Hedgehog pathway, which form the heart of a profibrotic signature in GVHD.
This study demonstrates a new mechanism in which chronic inflammation perpetuates fibrosis via activation of JUN, CD47, IL-6, and the Hedgehog pathway, which form the heart of a profibrotic signature in GVHD.