Congratulations to Steffen Böttcher for receiving a competitive Swiss Cancer League research grant in order to study the molecular mechanisms of the dominant-negative effect (DNE) of TP53 missense mutations in pre-malignancies and overt cancer! The overarching goal of this project is to devise novel therapeutic strategies to overcome the DNE using a combination of unique genome-engineered in vitro model systems with unbiased high-throughput screening approaches.